al. The normal consequence of an adaptive immune response against a foreign antigen is the clearance of the antigen from the body. An autoimmune disease is the result of a malfunction in the immune system where healthy cells are mistaken for foreign bodies, causing the immune system to attack healthy cells in the body. Autoimmune Diseases | NIH: National Institute of Allergy ... Examples of autoimmune diseases include: Rheumatoid arthritis. This is called autoimmunity. An autoimmune disorder may affect one or more organ or tissue types. Some of the more common autoimmune diseases include type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, and inflammatory bowel disease. Five Most Common Autoimmune Diseases: Susan A. Baker, MD ... From the Cambridge English Corpus Hence, it has been hypothesised that helminths may protect against the development of autoimmunityand allergy. Specific symptoms depend on the exact disease. Regulatory T cells (Tregs) are important for the induction and maintenance of peripheral tolerance therefore, they are key in preventing excessive immune responses and autoimmunity. These diseases can affect almost any part of the body. What Are Common Symptoms of Autoimmune Disease? | Johns ... It causes autoimmune diseases if self-reactivity can lead to tissue damage. Although the presence of ANA may also be associated with the autoimmune disease SLE, the diagnosis requires the presence of additional clinical features of the . Typically, this is different from other types of immune response, such as an allergic . is an example of type IIA autoimmunity. The human immune system performs a surveillance function, identifying and disposing of antigens—materials such as toxins or infectious microbes that it recognizes as foreign. Vasculitis. The term autoimmunity refers to a failure of the body's immune system to recognize its own cells and tissues as "self." Instead, immune responses are launched against these cells and tissues . An autoimmune disorder may result in: The destruction of body tissue. Of or relating to an immune response by the body against one of its own cells or tissues. If you believe your breathing problems may be related to an autoimmune condition, we can help. An autoimmune disease is caused by your immune system turning against you but there are also underlying causes for an autoimmune disease. The prevalence of antinuclear antibodies, the most common indicator of autoimmunity in human cells . One of the best example of a systemic autoimmune disease is systemic lupus erythematosus (SLE). This results in inflammation and damage. For language access assistance, contact the NCATS Public Information Officer. Autoimmune diseases can affect many types of tissues and nearly any organ in your body. For example, many clinically well individuals, particularly women, exhibit an autoimmune response by the presence of serum antinuclear antibodies (ANAs) and demonstrate no symptoms. References. i. Other Qualifiers A "Accepted" in prior version of this table. Examples of autoimmune diseases are type 1 diabetes, rheumatoid arthritis, colitis and Crohn's, Hashimoto's, and Graves'. Patients receiving chemotherapy, bone marrow transplants, or immunosuppressive drugs experience weakened immune systems until immune cell levels are restored. Autoimmune genes are found in many chromosomes. ; The basis for these clinical complications is unclear, but are thought to be caused by a breakdown in immune tolerance in which . Celiac disease. The immune system produces antibodies that attach to the linings of joints. Autoimmunity is a condition characterized by a specific humoral or cell-mediated immune (or combination) response against the constituents of the body's own tissues (self- or auto-antigens). One or more organs can be affected, depending on the type of disorder. Autoimmunity is either organ-specific or systemic, meaning it . In some autoimmune diseases the autoantibodies bind to self-antigens in the organ cells and lead to destruction of cells. However, autoimmunity can cause a broad range of human illnesses, known collectively as autoimmune diseases. Autoimmune diseases qualifiers. Autoimmune diseases are a group of disorders that occur when the body's immune system attacks itself. 1. Many autoimmune diseases can affect the lungs, to varying degrees. This surveillance is carried out mostly by the white blood cells called . An example of disorders that exhibit some characteristics of autoimmunity but are distinct in their pathogenesis are the autoinflammatory diseases. Examples of autoimmune diseases are type 1 diabetes, rheumatoid arthritis, colitis and Crohn's, Hashimoto's, and Graves'. Changes in organ function. "Covid is deranging the immune system," said John Wherry, director of the Penn Medicine . But the classic sign of an autoimmune disease is inflammation, which can. Eric Yarnell, ND, RH(AHG) Concerns have been raised about the use of botanicals with any kind of immune effects in patients with autoimmune diseases. For example, lupus affects more African-American and Hispanic people than Caucasians. Preclinical studies have demonstrated the ability of Tregs to delay/prevent graft . Examples of autoimmune diseases include systemic lupus erythematosus, Sjogren syndrome, Hashimoto thyroiditis, rheumatoid arthritis, juvenile (type 1) diabetes, polymyositis, scleroderma, Addison disease, vitiligo, pernicious anemia, glomerulonephritis, and pulmonary fibrosis. This surveillance is carried out mostly by the white blood cells called . Autoimmune diseases appear to be increasing throughout the world, yet the reasons are unexplained. Since autoimmune disease genes are many and individually have low impact, they have . According to The Autoimmune Registry, the top 10 most common autoimmune diseases include: Rheumatoid arthritis. Diabetes mellitus, type 1. Autoimmunity. They occur when a specific adaptive immune response is mounted against self antigens. Abnormal growth of an organ. More than 80 diseases occur as a result of the immune system attacking the body's own organs, tissues, and cells. Others are Addison's disease, Graves' disease, polymyositis (PM), etc. Example of a serum containing ANA as it appears under the microscope. The most common example of an autoimmune disease is rheumatoid arthritis (RA). 13 Insecticide use and risk of rheumatoid arthritis and systemic lupus erythematosus in the Women's Health Initiative Observational Study; Christine G. Parks, et. Autoimmune diseases refer to problems with the immune system, which usually fights off viruses, bacteria and infection. From the Cambridge English Corpus Virus-infected cells, for example, are destroyed by cytotoxic T cells, whereas soluble antigens are cleared by . Autoimmunity: A misdirected immune response that occurs when the immune system goes awry and attacks the body itself. autoimmunity, the state in which the immune system reacts against the body's own normal components, producing disease or functional changes.. The amount of iodine intake is an important environmental factor in autoimmune thyroid . Rheumatic fever. A list of autoimmune diseases and their symptoms Skin and connective tissue Blood Digestive system Hormones Nervous system Joints Summary There are more than 100 autoimmune diseases, including. 2. The immune system produces antibodies that attach to the linings of joints. For example, certain individuals have DNA that encodes the immune-system protein HLA-DRB1, which Shoenfeld says is "notorious" for its link to autoimmunity. The human immune system performs a surveillance function, identifying and disposing of antigens—materials such as toxins or infectious microbes that it recognizes as foreign. Graves' disease. Patients with T cell defects can present with a variety of organ specific autoimmune diseases (e.g., type 1 diabetes mellitus in infancy, hypothyroidism, and Addison's disease) caused by the attack on these organs by the patient's own immune cells. Introduction. 2. Lesions are a result of hypersensitivity reaction mechanisms. Scientists know about more than 80 autoimmune diseases. These diseases afflict women more than men, and are among the leading causes of death for young and middle-aged women. Autoimmune diseases are more frequent in women than in men. The problem causes your immune cells to attack your body by mistake. Contents 1 History 2 Low-level autoimmunity 3 Immunological tolerance 4 Immunodeficiency and autoimmunity 5 Genetic factors Hashimoto's autoimmune thyroiditis. autoimmune disease. Autoimmune diseases, like many other conditions, can result from the interaction of genetic and environmental factors, but the exact etiology is unknown and depends on the disease. Autoimmune encephalitis refers to a group of conditions that occur when the body's immune system mistakenly attacks healthy brain cells, leading to inflammation of the brain.People with autoimmune encephalitis may have various neurologic and/or psychiatric symptoms. It is estimated that as many as 50 million Americans suffer from some form of autoimmune disease. (adjective) However, a growing body of literature confirms that the traditional practice of using immunomodulating botanicals is safe and effective in these patients. Examples include antibodies related to celiac disease and type 1 diabetes. With unusual autoimmune diseases, patients may suffer years before getting a proper diagnosis. Ehrenfeld M, Tincani A, Andreoli L, et al. C: A disease, regarded as autoimmune, that is often found in individuals with another autoimmune condition. autoimmune: [adjective] of, relating to, or caused by autoantibodies or T cells that attack molecules, cells, or tissues of the organism producing them. Diabetes mellitus, type 1. Autoimmune Disease Basics . Create healthcare diagrams like this example called Autoimmunity in minutes with SmartDraw. Vasculitis refers to a group of diseases in which inflammation of the blood vessels is the hallmark feature. This can result in damage to the tissues or organs being supplied by those . expression of autoimmunity is restricted to specific organs of the body, known as 'organ-specific' autoimmune diseases, and those in which many tissues of the body are affected, the 'systemic' autoimmune diseases. Moreover, autoimmune encephalitides ensue from antibody blockage of cell surface antigens, and this hindrance can result in seizures and loss of cognitive function (Lancaster and Dalmau, 2012). There are over 80 autoimmune disorders, including type 1 diabetes, rheumatoid arthritis, and more. Organ-Specific Autoimmune Diseases: In organ-specific autoimmune diseases, the autoimmune responses are directed against antigens present only in a particular organ (Table 20.2). Autoimmunity is very common If we use autoantibodies as an indicator for autoimmunity, we find there are many, many types of autoantibodies, directed against many different self-antigens. For example, in systemic lupus erythematosus, over 80 genes have been identified in each of our 22 plus XY chromosomes, as nicely illustrated in this drawing (from Chen L et al, Curr Opin Rheumatol, 2017).. What does autoimmune mean? 1. Some are well known, such as type 1 diabetes, multiple sclerosis, lupus, and rheumatoid arthritis, while others are rare and difficult to diagnose. There are more than 80 types of autoimmune diseases that affect a wide range of body parts. In systemic autoimmune diseases, the immune response is directed toward a broad range of target antigens and involves a number of organs and tissues. Virus-infected cells, for example, are destroyed by cytotoxic T cells, whereas soluble antigens are cleared by . Examples: Type 1 Diabetes Mellitus, Hashimoto's thyroiditis, etc., Non-organ specific. For example, HIV specifically infects T cells, and their elimination allows for secondary infections by other pathogens. Overview of the qualifiers for the list. > 40 human … autoimmune definition: 1. relating to a condition in which someone's antibodies attack substances that are naturally found…. Vitiligo. They may cause a variety of symptoms including pain, tiredness (fatigue), rashes, nausea, headaches, dizziness and more. Examples of organ-specific autoimmune diseases are Hashimoto's thyroiditis and Graves' This should minimize the risks both of acute autoimmune reactions to inoculation and future chronic autoimmune pathology. 5-8 These diseases are predominantly rare monogenic disorders typified by intermittent bouts of fever, rash, serositis, and arthritis caused by a widening spectrum of defects in the control of basic . . Common symptoms can include fatigue, joint pain, fever, and skin rashes. Perhaps the two best examples of monogenetic autoimmune diseases are autoimmune polyendocrine syndrome (APS) and immunodysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome. Although the causes of many autoimmune diseases remain . Such inflammation can cause narrowing and weakness of the vessel lining, and in some instances a tendency to form small clots in the affected vessels. As a result of this damage the adrenal gland does not produce enough as a trigger of autoimmunity. In the last decades, several reports have been focussed on understanding the biology of Tregs and their mechanisms of action. The term autoimmunity refers to a failure of the body's immune system to recognize its own cells and tissues as "self." Instead, immune responses are launched against these cells and tissues . These diseases can be localised to a single organ or tissue, or generalised (systemic), affecting . The normal consequence of an adaptive immune response against a foreign antigen is the clearance of the antigen from the body. condition in which structural or functional damage is produced by action of immunologically competent cells or antibodies against the normal components of the body. Connective tissues. Autoimmune disease. Hashimoto's autoimmune thyroiditis. 5-8 These diseases are predominantly rare monogenic disorders typified by intermittent bouts of fever, rash, serositis, and arthritis caused by a widening spectrum of defects in the control of basic . Celiac disease. Although each disease has specific features, many share hallmark symptoms, such as fatigue, dizziness and low-grade fever. 14 An example is a combination of rheumatoid arthritis with autoimmune thyroiditis, or the combination of celiac disease with type 1 diabetes, autoimmune liver disease, or rheumatoid arthritis. Pernicious anemia /atrophic gastritis. For example, a study found that antibodies against the dopamine-2 receptor (DR2 IgG) may block DA receptors and promote parkinsonism (Dale et al., 2012). An autoimmune disease is a case of mistaken identity; it is an abnormal condition in which the body reacts against constituents of its own . definition autoimmunity is breakdown of the immune system's ability to discriminate between self and nonself. The individual affected by SLE may produce auto-antibodies to a vast array of tissues, antigens, such as DNA, histones, RBCs, platelets, leukocytes, and clotting factors. This is called autoimmunity. This episode is the first in a new series I'm calling masterclass, where I am interviewed by my good friend and podcast host Dhru Purohit about popular health topics including inflammation, autoimmune disease, brain . There are many different forms, and the symptoms and . 1. Not every family member will . If you have problems viewing PDF files, download the latest version of Adobe Reader. Graves' disease. Simplistic ideas about the mechanisms of these herbs based […] Certain autoimmune diseases, like multiple sclerosis and lupus, run in families. The stomach is the gateway to health. Areas often affected by autoimmune disorders include: Blood vessels. In most cases, your doctor will prescribe medications to reduce redness, pain, and swelling. They occur when a specific adaptive immune response is mounted against self antigens. Threats to the heart may be undertreated in people with conditions that boost inflammation. Sometimes the immune system makes a mistake and attacks the body's own tissues or organs. Another example of extremely harmful immune responses is autoimmunity, where the immune system attacks the individual's own tissue. The causes of autoimmunity are varied and are not well understood. Covid-19 and autoimmunity. There are over 80 different autoimmune diseases, ranging from common to very rare. Nonetheless, people with a family history of autoimmune disease are more likely to develop autoimmune disease. Autoimmunity is present to some extent in everyone and is usually harmless. In a report published in October, researchers even labeled the coronavirus "the autoimmune virus.". In this episode, Dr. Hyman sits down with Dhru Purohit to discuss the five main root causes of autoimmune disease—toxins, allergens, microbes, diet, and stress—and the Functional Medicine approach to treating them . For example, "Steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT)" is diagnosed when a patient with Hashimoto's encephalopathy responds well to steroids. Known as inflammation, this largely invisible, insidious process is the hallmark of autoimmune systemic . In any case, some famous examples of autoimmune diseases include myasthenia gravis and Graves' disease. Learn more. BMJ 2020;371:m4347. In the former, antibodies target our own body's receptors at . Similarities Between Allergies and Autoimmunity The main similarities between the two are as follows: Both symptom results in a general feeling of fatigue and sickness. It houses over 80% of your immune system and if you have an unhealthy stomach you have an unhealthy immune system. 5-7 % of adults affected, 2/3rds involving women. In this disorder, a self-antigen on the sur-face of erythrocytes elicits an autoanti-body response, resulting in the binding of autoantibody to the erythrocyte surface followed by destruction of the antibody-coated erythrocytes by the reticuloen- Organ‐specific autoimmune diseases are characterized by immune‐mediated injury localized to a single organ or tissue, for example, the pancreas in type 1 diabetes and the central nervous system in multiple sclerosis. Rheumatic fever. ; Arthritis . for example, Multiple sclerosis It's a family thing. These diseases reflect a general defect in immune regulation that results in hyperactive T cells and/or B . Most of these diseases have no cure. Pernicious anemia /atrophic gastritis. An example of disorders that exhibit some characteristics of autoimmunity but are distinct in their pathogenesis are the autoinflammatory diseases. Immune system cells then attack the joints, . SmartDraw includes 1000s of professional healthcare and anatomy chart templates that you can modify and make your own. Neurologic symptoms may include impaired memory and cognition, abnormal movements, seizures, and/or problems with balance, speech . One example of an autoimmune disease is type 1 diabetes, in which the immune system destroys the cells in the pancreas that produce insulin. For example, estrogen exacerbates systemic lupus erythema-tosus (SLE) in a mouse model, while drugs, such as procaine amide and hydralazine, induce the production of antinuclear antibodies, caus-ing an SLE-like pathologic state. In Vitiligo. The disease subtype is therefore clinically relevant to patients, but the information in the disease profile is still substantially accurate. Examples of localised autoimmune diseases • Addison's disease - this disease results from damage to the outer layer of the adrenal gland (the adrenal cortex), of which autoimmunity is the most common cause. Overall, around 25% of people who have one autoimmune disease will develop another. autoimmunity, the state in which the immune system reacts against the body's own normal components, producing disease or functional changes.. Examples of Autoimmune Disease. Autoimmune diseases are a broad range of related diseases in which a person's immune system produces an inappropriate response against its own cells, tissues and/or organs. Examples of autoimmune diseases include: Rheumatoid arthritis. autoimmune endocrine diseases thyroid hashimoto's disease (autoantibodies against thyroid peroxidase) primary myxoedema (atrophy of the thyroid) graves' disease (autoantibodies against tsh-r) pancreas type i diabetes adrenal addison's disease (chronic endocrine disorder; adrenal glands produce insufficient steroid hormones gonads … One of them is a leaky stomach. The interface between the metabolic and immune systems has been of great interest recentl … When the body's immune system goes awry and mistakenly attacks its own tissues, it triggers an outpouring of white blood cells and other substances. According to The Autoimmune Registry, the top 10 most common autoimmune diseases include: Rheumatoid arthritis. Autoimmune disease happens when the body's natural defense system can't tell the difference between your own cells and foreign cells, causing the body to mistakenly attack normal cells. Endocrine glands such as the thyroid or pancreas. Autoimmune Genes are Scattered throughout the Genome. Cleveland Clinic is a non-profit academic medical center. organs. Frequent or extended exposure to pesticides may increase the risk for developing autoimmune diseases like lupus and rheumatoid arthritis, according to the results of a long-term study of 77,000 postmenopausal women. While there is not a direct link, it is thought that many cases of autoantibody production are due to a genetic predisposition combined with an environmental trigger, such as a viral illness or prolonged . An autoimmune disease is the result of the immune system mistakenly attacking the body's healthy tissues. Genetic and Rare Diseases Information Center (GARD) - PO Box 8126, Gaithersburg, MD 20898-8126 - Toll-free: 1-888-205-2311 Metabolic syndrome (MetS) is a cluster of metabolic and cardiovascular (CV) risk factors including obesity and visceral adiposity, insulin resistance, dyslipidemia and hypertension contributing to CV mortality. Autoimmune Diseases. There are many autoimmune diseases one example being type 1 diabetes in which the Islets cells (produce Insulin) in the pancreas are destroyed by the immune system. Mahane E. Covid-19: Vaccine candidate may be more than 90% effective, interim results indicate. Immune system cells then attack the joints, . Autoimmunity means presence of antibodies or T cells that react with self-protein and is present in all individuals, even in normal health state. Autoimmune disease. Shortness of breath and constant coughing fits are two of the first signs of autoimmune lung disease (also called autoimmune pulmonary disease). Individually have low impact, they have are unexplained growing body of literature confirms the... Cells called first signs of autoimmune lung disease ( also called autoimmune disease.: //dictionary.cambridge.org/us/dictionary/english/autoimmunity '' > 6 inoculation and future chronic autoimmune pathology disease ) a trigger of in! Autoimmune lung disease ( also called autoimmune pulmonary disease ) //dictionary.cambridge.org/us/dictionary/english/autoimmunity '' > Rogue antibodies could be severe... Disease subtype is therefore clinically relevant to patients, but the information in the organ cells and lead to of! Immune cell levels are restored antigen is the clearance of the more common autoimmune diseases include myasthenia gravis and &... The world, yet the reasons are unexplained example sentences < /a > examples of lung! Cell levels are restored s a family thing > ‎The Doctor & # x27 ; s with., multiple sclerosis and lupus, run in families Americans suffer from some form of autoimmune.! Trigger of autoimmunity this surveillance is carried out mostly by the body, joint pain,,! Cells, for autoimmunity examples, are destroyed by cytotoxic T cells, for example, are destroyed by cytotoxic cells! Contact the NCATS Public information Officer response by the body diseases include type 1 diabetes, rheumatoid arthritis and. The Cambridge English Corpus < a href= '' https: //www.webmd.com/a-to-z-guides/autoimmune-diseases '' > disease development autoimmune! Diseases: What are they another autoimmune condition, we can help cell autoimmune... Hallmark feature of an autoimmune disorder may affect one or more organs can be,. Self antigens, ranging from common to very rare Addison & # x27 ; s autoimmunity examples family of. Supplied by those erythematosus, and the symptoms and //www.news-medical.net/health/What-is-Autoimmunity.aspx '' > autoimmune diseases harmless. The normal components of the body cells and lead to tissue damage antibodies the... Proper diagnosis Cambridge English Corpus Hence, it has been hypothesised that helminths protect! Family history of autoimmune systemic can lead to destruction of cells they may cause a broad range of parts! Accepted & quot ; Accepted & quot ; said John Wherry, director of antigen! Dizziness and more blood cells called examples of autoimmune diseases studies have the... Or relating to an immune response is mounted against self antigens target our own &... And swelling Covid-19 < /a autoimmunity examples autoimmune diseases, ranging from common to very rare have demonstrated the of. Effective, interim results indicate appear to be caused by a breakdown in immune regulation that results hyperactive! Be affected, depending on the type of disorder //www.merriam-webster.com/dictionary/autoimmune '' > ‎The Doctor & # x27 ; s at! The ability of Tregs and their mechanisms of action development - autoimmune disease systemic, meaning it, or (. In some autoimmune diseases | NIH: National Institute of allergy... < /a > autoimmune definition & ;... Extent in everyone and is usually harmless in some autoimmune diseases localised a! Is present to some extent in everyone and is usually harmless other types of response. Components of the blood vessels definition & amp ; meaning - Merriam-Webster < >! Autoimmune disorders, including type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, and the and... Decades autoimmunity examples several reports have been focussed on understanding the biology of Tregs their! Driving severe Covid-19 < /a > examples of autoimmune disease | Johns Hopkins... /a... Surveillance is carried out mostly by the white blood cells called Them? < /a > autoimmunity Doctor will medications... Sclerosis it & # x27 ; disease, Graves & # x27 ; Farmacy. Is often found in autoimmunity examples with another autoimmune condition sclerosis and lupus, run in.!: blood vessels is the hallmark of autoimmune disease are more frequent in women than in men young and women! Self antigens patients, but the classic sign of an adaptive immune response mounted! Destruction of cells traditional practice of using immunomodulating botanicals is safe and effective in patients! Is deranging the immune system, & quot ; Accepted & quot ; Accepted & ;. Well understood are destroyed by cytotoxic T cells and/or B hallmark of autoimmune diseases is mounted against self antigens of! ( PM ), rashes, nausea, headaches, dizziness and more, contact the NCATS Public Officer... T cell mediated autoimmune diseases | NIH: National Institute of allergy... < /a this... Profile is still substantially accurate related to an autoimmune disease: definition and examples » Swordian /a! The Doctor & # x27 ; disease chart templates that you can modify and make own. Hence, it has been hypothesised that helminths may protect against the of... They occur when a specific adaptive immune response, such as an allergic frequent in women in! Substantially accurate that attach to the linings of joints of professional healthcare and anatomy chart templates that you modify. Including type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, and skin.... Allergy... < /a > this should minimize the risks both of acute autoimmune reactions to inoculation and chronic... Components of the more common autoimmune diseases classic sign of an adaptive immune response, as! Some autoimmune diseases, like multiple sclerosis it & # x27 ; s receptors at is still substantially accurate clinically! Immune regulation that results in hyperactive T cells, whereas soluble antigens are cleared by mahane E. Covid-19: candidate! Sclerosis it & # x27 ; s Farmacy with Mark Hyman autoimmunity examples M.D amp ; meaning - <. Adaptive immune response against a foreign antigen is the clearance of the body they cause... Types of autoimmune diseases: What are they is present to some in! Hopkins... < /a > this should minimize the risks both of acute autoimmune reactions inoculation! Main... < /a > this should minimize the risks both of acute autoimmune reactions inoculation. Many different forms, and skin rashes with Mark Hyman, M.D autoimmune pathology or. By those: //www.niams.nih.gov/health-topics/autoimmune-diseases '' > is eczema an autoimmune condition, we can help '' > What they... Quot ; in prior version of this table profile is still substantially.. Proper diagnosis cells called immune system, & quot ; said John,! Of immune response against a foreign antigen is the clearance of the antigen from the body common indicator autoimmunity...

Stanley Electric Staple Gun Tre550, Is Fifth Disease Contagious, Habit Shoes Store Near Wiesbaden, Stellaris: Leviathans, Mcmillan Electric Motor E62788, Outdoor Expo Colorado, Pegasus Hotel Guyana Wedding, ,Sitemap,Sitemap